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Old Spiked Collar is a Keepsake that increases Zagreus' maximum health. It is obtained by giving Cerberus a gift of Nectar in the House of Hades. Its effects can be enhanced by clearing enough encounters with the keepsake equipped.
Removing the Old Spiked Collar between levels will remove the health bonus granted by the item.
From Cerberus; you share a Ferocious Bond
The hound of hell has entrusted all his loyalty in his master, and his master's son.