Artifacts are rewards for winning Underworld Encounters which either benefit Zagreus 's current escape attempt or can be spent to obtain permanent benefits on future attempts.
These can be spent on permanent upgrades and are obtained from standard Encounters. These resources persist after a run (i.e., they are not lost whether or not Zagreus succeeded in escaping) and can be used back in the House of Hades.
|Used to unlock Infernal Arms, and various abilities in the Mirror of Night.|
|Used to upgrade abilities at the Mirror of Night.|
|Used to renovate the Underworld and the House of Hades at the House Contractor.|
|Used as gifts for characters, increasing your affinity with them and unlocking Keepsakes.|
These can be spent on permanent upgrades and are obtained by completing Bounties.
|Used to gifts for characters, increase your affinity with them and unlocking Companions.
(Ambrosia can only be gifted to characters you have done favors for.)
|Used for pricier renovations from the House Contractor.|
|Used to unlock and upgrade Aspects of the Infernal Arms.|
These artifacts improve Zagreus's power in his current escape attempt. The benefits these grant will be lost after a run ends. With the exception of the Loyalty Card, Red Onion, and Anvil of Fates, all of these Artifacts are rewards for normal Encounters.
|Removes one Daedalus Hammer upgrade, then gives you two.
(The upgrades you lose and receive are applied at random.)
|Increases Zagreus's max health by 25 for that escape attempt.|
|Used to either purchase consumables at Wells of Charon or Artifacts and Boons from Charon.|
|Used to make a major modification to Zagreus's current weapon, for that escape attempt.|
|Reduces prices of items from the Well of Charon and Charon's shop by 20% for that escape attempt.|
|Increase the effectiveness of an existing Boon.|
|Restores 1 .
(Only obtained when failing a Perfect Clear challenge in Erebus.)